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Eligible participants were nonpregnant, nonlactating women who had sex at least once in their lifetime

Eligible participants were nonpregnant, nonlactating women who had sex at least once in their lifetime

To the best of our knowledge, this study was the first to identify VMB biomarkers by performing a systematic exploration of the potential confounding variables of HPV infection . After obtaining metagenomics sequences and other factors through the eHealth platform, a correlation approach was utilized to explore the association between the candidate biomarkers and personal factors. We define stable microbiomes as biomarkers that are not influenced by the status of other crucial factors. The correlation p-value is utilized to select the stable biomarker panels as overlapping for each category.

Participants recruitment and sample collection

This research was approved by the ethics committee of the Institutional Review Board at Beijing Genomics Institution (BGI-IRB 21054). This research is recorded with , ChiCTR2100049221. The recruitment of participants for this study began on and was carried out in a community setting in Shenzhen, Mainland China. Read more